The Information Technology and the Quality Assurance Working Groups of the WMDA worked together in the Search Algorithm Subcommittee. They have established guidelines that will insure that international unrelated donor searches proceed in a timely fashion and that issues of HLA nomenclature do not impede their progress. The guidelines will also assist registries and cord blood banks in designing their search algorithms to incorporate and compare all approved HLA assignments and will lead to more accurate searches.
Since the advent of the European Marrow Donor Information System (EMDIS) in the first half of the last decade, fully automated data exchange between registry computer systems has been playing an ever increasing role in the international search for unrelated donors of blood progenitor cells.This exchange, however, has been hampered by different local conventions used to present HLA data and limited by the need to extend the official WHO nomenclature for practical reasons and to cross-validate HLA data obtained with different methods and/or at different loci. The guidelines have been developed by the World Marrow Donor Association in order to standardize the nomenclature to be used and the plausibility checks to be applied in the international electronic exchange of HLA typing data among unrelated volunteer hematopoietic stem cell donor registries and umbilical cord blood banks. Two reference web sites have been designated to maintain and update the approved HLA nomenclature and all ancillary information needed:
- Link to website that describes HLA nomenclature files in WMDA format
- Link to website with codes which include multiple allele alternatives
Publications and Tools
C. Hurley et al., 'Overview of Registries, HLA Typing and Diversity and Search Algorithms' Tissue Antigens (2007) 69, suppl 1:305
C. Hurley et al., 'Hematopoietic Stem Cell Donor Registry Strategies for Assigning Search Determinants and Matching Relationships'. Bone Marrow Transplantation (2004) 33, 443-450
Link to IMGT/HLA Database with information about search strategies of other registries.
Link to allelefrequencies website.
W. Bochtler et al. 'World Marrow Donor Association Guidelines for Use of HLA Nomenclature and it's Validation in the Data Exchange Among Hematopoietic Stem Cell Donor Registries and Cord Blood Banks'. Bone Marrow Transplantation (2007), 39, 737-741.
W. Bochtler, M. Maiers, J. Bakker, M. Oudshoorn, S. Marsh, D. Baier, C. Hurley, C. Mueller, 'World Marrow Donor Association framework for the implementation of HLA Matching programs in hematopoietic stem cell donor registries and cord blood banks'. Bone Marrow Transplantation (2011) 46, 338-343.
The paper: 'World Marrow Donor Association Guidelines for Use of HLA Nomenclature and Its Validation in the Data Exchange Among Hematopoietic Stem Cell Donor Registries and Cord Blood Banks (Version 2.0)' is currently approved by the WMDA Board and submitted for publication.
S.G.E. Marsh, E.D. Albert, W.F. Bodmer, R.E. Bontrop, B. Dupont, H.A. Erlich, M. Fernandez-Vina, D.E. Geraghty, R. Holdsworth, C.K. Hurley, M. Lau, K.W. Lee, B. Mach, M. Maiers, W.R. Mayr, C.R. Muller, P. Parham, E.W. Petersdorf, T. Sasazuki, J.L. Strominger, A. Svejgaard, P.I. Terasaki, J.M. Tiercy and J. Trowsdale 'Nomenclature for factors of the HLA system, 2010' Tissue Antigens 75, 291–455
The Working Group on HLA Serology to DNA Equivalents seeks the help of the HLA community.
Regularly updates of the 'HLA Dictionary' are produced in which HLA alleles are presented with their associated serologically defined antigens. Many alleles are poorly, if at all, identified at the serologic level. Under the auspices of the World Marrow Donor Association this Working Group on HLA Serology to DNA Equivalents (Rhonda Holdsworth present chair), Marcelo Fernandez-Vina, Carolyn Hurley, Marie Lau, Steven Marsh, Harriet Noreen, Michelle Setterholm and Martin Maiers) will continue its activities and further update and extend this "Dictionary". An updated version was published recently by Schreuder et al. in 2004. The Working Group seeks the help of the HLA community.
Individual laboratories are encouraged to contribute their serologic information for DNA based HLA alleles with unknown or poorly defined serologic specificities to the Working Group using this form.
PLEASE RETURN TO:
WMDA Working Group on HLA Serology to DNA Equivalents
PO Box 354, South Melbourne, VIC 3205, Australia
IMGT/HLA: Sequence databases for the study of the major histocompatibility complex
The IMGT/HLA database provides a centralized repository for the sequences of the alleles named by the WHO Nomenclature Committee for Factors of the HLA System. Since its initial release the database has grown and is the primary source of information for the study of sequences of the human major histocompatibilty complex.
See publication in: Nucleic Acids Res 31:311-314, 2003
Last update: 22:42 18/06 2012